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What are the factors affecting throat swab sampling for nucleic acid detection? Shenzhen Hua Rui Kang biological tell you

Author: Site Editor Publish Time: 2022-06-10 Origin: Site

In the current epidemic, the detection of new coronary nucleic acids and antigens is essential, and I believe we are all familiar with the small sampling "swab" at the time of testing.

 

As the first part of the test, many friends have questions about whether single-use swabs are "sterile" or "non-sterile" and whether they need to be sterilized. What is the material used for sampling swabs in general?

 

Single-use swabs are different from swabs used in daily life and are medical devices. Common head materials for sampling swabs include flocking, sponge, etc. Need to have easy to elute, no toxic effect on pathogens and contact with the cellular tissue, does not affect the subsequent detection and other characteristics.

 

02 What is "sterile", what is "non-sterile" / "not sterilized" sampling swab manufacturers Shenzhen Huarui Kang biological said.

 

Sterile": refers to the state of no viable microorganisms, the medical device labeled "sterile" after sterilization, the theoretical probability of the existence of viable microorganisms should not exceed 10 negative 6 times, so in some particularly demanding use environment, only need "sterile" Medical Devices

 

Non-sterile / non-sterile]: These medical devices are not as stringent as "sterile" medical devices, but they are not as "sterile". All medical devices must meet certain health requirements, such as strict control of the number of microorganisms, in order to be qualified to market.

 

Sampling head is the core components of disposable sampling swabs, for example, the sampling head of the ordinary type swab type swabs available medical skim cotton, polyester short fiber, electrostatic flocking fabric and other materials made, if the use of "non-sterile" medical skim cotton, must comply with China's pharmaceutical industry standards "medical skim cotton", the manufacturer must provide microbial The manufacturer must provide microbiological limits for the reference of medical institutions and other users.

03 "With bacteria" sampling swabs will affect the antigen detection?

 

This is a misunderstanding arising from the confusion between bacteria and viruses. It is important to understand that the antigen test "looks" for the N protein of the neo-coronavirus carried by the neo-coronavirus in the neo-coronavirus infected person, and the display window of the reagent strip contains an antibody that recognizes the viral protein and acts as a dam to intercept only the antibody-latex/colloidal gold conjugate that has bound the viral antigen and is presented as antibody-antigen-antibody-latex/colloidal gold conjugate (antibody-antigen-antibody-latex/colloidal gold conjugate). Colloidal gold binding form (referred to as double antibody sandwich method), and thus in the display window color. Therefore, even if the sample swab is "bacterial", the test card will "ignore" it and concentrate on finding the N protein of the NIC virus carried by the NIC. Since the card is not interfered by "bacteria", it will not affect the result of antigen detection.

 

04 Do "non-sterile"/"non-sterile" swabs need to be disinfected before use?

 

It is not recommended to disinfect the swab head with a household disinfectant as there is a risk that the disinfectant may damage the sample and thus affect the antigen test results. Sampling swabs are medical devices that are used to scrape cells and viruses into extracts/viruses for testing purposes.

 

05 Why are some swabs "yellow" and how is it caused?

 

We mentioned above that some of the sampling swab head material is sponge (also known as polyurethane foam), this kind of swab will be due to the characteristics of its material, in the light (ultraviolet), high temperature conditions caused by thermal oxidation yellowing, or exposure to air nitrogen oxides (NOx) caused by gas fumigation yellowing [1, 2].

 

This is an unavoidable phenomenon in the current polyurethane foam production process, so it is recommended to avoid or slow down the yellowing by storing at 2-30°C away from light.

 

Oral sampling swab manufacturers which is a good price to purchase? Oral sampling swab manufacturers Huarui Kang biological to you

 

To know which oral sampling swab manufacturers good price procurement first we need to understand what is oral sampling swab, oral sampling swab what is used, the following we will learn together.

What is oral sampling swab

Oral swab is a (with our daily cotton swab is almost the same except it is used to extract DNA products) the swab into the oral cavity, hanging back and forth in the oral cavity wall swab many times, packaged and sent to the detection agency testing can be.

 

The principle is to collect oral epithelial mucosal cells, and DNA identification is accomplished by testing the DNA in these cells.

 

Oral Swab has developed a product that collects microbial DNA from saliva. This is an all-in-one system that can collect, stabilize, transport and purify DNA from saliva, providing a painless, risk-free way to collect microbial DNA for disease control and prevention.

 

Oral swabs have the same test data as blood, are painless, very scientific and credible, and many genetic companies are recommending the use of oral mucosa. Oral swabs have been shown in numerous clinical trials abroad that nylon flocked swabs have better collection and delivery of clinical biological samples than ordinary sterile swabs, especially for those samples that cannot be delivered in a timely manner and are left in place for too long.

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